In a 2026 trial of 410 people, a year of the popular NAD+ supplement nicotinamide riboside left early Parkinson's patients slightly worse than placebo, by less than patients would notice, in a trial not designed to show harm.
Field Notes
All Entries
Nicotinamide Riboside Did Slightly Worse Than Placebo in Early Parkinson's
Is Lithium a True Anti-Aging Compound?
The companion to the episode. Every study behind the lithium-for-your-brain claim, tested one at a time, with the water-concentration data and the one measurement that changes the question.
Can You Actually Lower Your Biological Age?
Your “biological age” test is making a prediction, not taking a measurement. Why that changes what the number means. A test tells you your body
Tattoo ink ends up in your lymph nodes. Here's what that means for your cancer risk.
Two studies asked the same question about tattoos and melanoma and got opposite answers. Here's what that contradiction actually reveals, and what the evidence can and can't tell you yet.
Does Vitamin D Without K2 Calcify Your Arteries?
The claim that vitamin D needs K2 or it hardens your arteries, measured against the trials that actually scanned people's arteries.
Creatine Is Sold for Your Brain. We Still Can't Reliably Measure Whether It Arrives.
Everyone is selling creatine for the brain now. Thirty years of research, and the delivery question is still open.
Apigenin Is Trending For Sleep And NAD+. Here Is What The Science Says.
The two claims driving apigenin sales have the weakest human evidence. The preclinical data that's genuinely compelling isn't on the label.
Folic Acid: Poison, Useless, or the Most Successful Supplement in History?
The most successful fortification in modern history. The internet says it's toxic. The answer involves an enzyme nobody's talking about.
Every Magnesium Form Is Sold by Organ. The Human Evidence Doesn't Exist
Threonate for brain. Glycinate for sleep. The organ-targeting map is everywhere. A systematic review found zero human studies behind any of it.
Making Sense of the New Dietary Guidelines Controversy
The 2025-2030 guidelines sparked outrage over seed oils and saturated fat. Here's what the committee actually wrote.
The Truth About Rancid Fish Oil
Omega-3 supplements oxidize. The question is how much, how fast, and whether the testing data matches what's on the label.
Field Notes
The week's most important human science, read in full.
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